Collectivity evolution in the neutron-rich Pd isotopes towards the N=82 shell closure

The neutron-rich, even-even 122,124,126Pd isotopes has been studied via in-beam gamma-ray spectroscopy at the RIKEN Radioactive Isotope Beam Factory. Excited states at 499(9), 590(11), and 686(17) keV were found in the three isotopes, which we assign to the respective 2+ -> 0+ decays. In addition, a candidate for the 4+ state at 1164(20) keV was observed in 122Pd. The resulting Ex(2+) systematics are essentially similar to those of the Xe (Z=54) isotopic chain and theoretical prediction by IBM-2, suggesting no serious shell quenching in the Pd isotopes in the vicinity of N=82

The Effelsberg survey of FU Orionis and EX Lupi objects I. -- Host environments of FUors/EXors traced by NH3_3

FU Orionis (FUor) and EX Lupi (EXor) type objects represent two small, but rather spectacular groups of low-mass, young eruptive stars. Outbursts of several magnitudes are observed, attributed to enhanced accretion from the circumstellar disk onto the central protostar. The host molecular environments of FUors/EXors are poorly explored due to the scarcity of systematic molecular line observations. We carried out the first dedicated survey of the molecular environments of a large sample of FUors/EXors, observing a total of 51 sources with the aim of studying the ammonia (NH$_3$) emission in their host environments. We observed the ammonia (J,K)=(1,1), (2,2), and (3,3) inversion transitions using the Effelsberg 100-m radio telescope. We derived H$_2$ column densities and dust temperatures using archival Herschel SPIRE data. We detected the (1,1) transition toward 28 sources and the (2,2) transition toward 12 sources, while the (3,3) transition was detected toward only two sources. We find kinetic temperatures between ~12 K and 21 K, ammonia column densities from $5.2\times10^{13}\,cm^{-2}$ to $3.2\times10^{15}\,cm^{-2}$, and fractional ammonia abundances with respect to H$_{2}$ from $4.7\times10^{-9}$ to $1.5\times10^{-7}$. The results are comparable to those found in infrared dark clouds (IRDCs). Kinetic analysis suggests that most of the eruptive stars in our sample reside in rather quiescent (sonic or transonic) host environments. Our NH$_3$ observations and analysis of the SPIRE dust-based H$_2$ column density maps confirm the presence of dense material toward 7 sources in our sample; additional sources might also harbour dense gas based on their NH$_2$ (2,2) detections, might indicate an earlier phase than originally classified. Based on our results, we suggest observations targeting additional molecular lines would help to refine the evolutionary classification of eruptive stars.Comment: 20 pages, 2 figures, accepted for publication in A&

Radial Growth of Qilian Juniper on the Northeast Tibetan Plateau and Potential Climate Associations

There is controversy regarding the limiting climatic factor for tree radial growth at the alpine treeline on the northeastern Tibetan Plateau. In this study, we collected 594 increment cores from 331 trees, grouped within four altitude belts spanning the range 3550 to 4020 m.a.s.l. on a single hillside. We have developed four equivalent ring-width chronologies and shown that there are no significant differences in their growth-climate responses during 1956 to 2011 or in their longer-term growth patterns during the period AD 1110–2011. The main climate influence on radial growth is shown to be precipitation variability. Missing ring analysis shows that tree radial growth at the uppermost treeline location is more sensitive to climate variation than that at other elevations, and poor tree radial growth is particularly linked to the occurrence of serious drought events. Hence water limitation, rather than temperature stress, plays the pivotal role in controlling the radial growth of Sabina przewalskii Kom. at the treeline in this region. This finding contradicts any generalisation that tree-ring chronologies from high-elevation treeline environments are mostly indicators of temperature changes

Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I

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The Effelsberg survey of FU~Orionis and EX~Lupi objects II. H2O maser observations

Funding: Zs.M.Sz. acknowledges funding from a St Leonards scholarship from the University of St Andrews. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 716155 (SACCRED).Context. FU Orionis (FUor) and EX Lupi (EXor) type objects are two groups of peculiar and rare pre-main sequence low-mass stars that are undergoing powerful accretion outbursts during their early stellar evolution. Although water masers are widespread in star-forming regions and serve as powerful probes of mass accretion and ejection on small scales, little is known about the prevalence of water masers toward FUors and EXors. Aims. We aim to perform the first systematic search for the 22.2 GHz water maser line in FUors and EXors in order to determine its overall incidence in these eruptive variables and to facilitate high angular-resolution follow-up observations. Methods. We used the Effelsberg 100-m radio telescope to observe the H2O (616 – 523) transition at 22.2GHz toward a sample of 51 eruptive young stellar objects. Results. We detected a total of five water masers in our survey; three are associated with eruptive stars, equivalent to a detection rate of ~6% for our sample of eruptive sources. These detections include one EXor, V512 Per (also known as SVS 13 or SVS 13A), and two FUors, Z CMa, and HH 354 IRS. This is the first reported detection of water maser emission towards HH 354 IRS. We also detected water maser emission in our pointing towards the FUor binary RNO 1B/1C, which most likely originates from the nearby deeply embedded source IRAS 00338+6312 (~4″ from RNO 1B/1C). Emission was also detected from H2O(B), (also known as SVS 13C), a Class 0 source ~30″ from the EXor V512 Per. The peak flux density of H2O(B) in our observations, 498.7 Jy, is the highest observed to date, indicating that we have serendipitously detected a water maser flare in this source. In addition to the two non-eruptive Class 0 sources (IRAS 00338+6312 and H2O(B)/SVS 13C), we detected maser emission towards one Class 0/I (HH 354 IRS) and two Class I (V512 Per/SVS 13A and Z CMa) eruptive stars. Conclusions. Despite the low detection rate, we demonstrate the presence of 22.2 GHz water maser emission in both FUor and EXor systems, paving the way to radio interferometric observations to study the environments of these eruptive stars on small scales. Comparisons of our data with historical observations spanning several decades suggest that multiple water maser flares have occurred in both V512 Per and H2O(B).Publisher PDFPeer reviewe

Improved stability regions for ground states of the extended Hubbard model

The ground state phase diagram of the extended Hubbard model containing nearest and next-to-nearest neighbor interactions is investigated in the thermodynamic limit using an exact method. It is found that taking into account local correlations and adding next-to-nearest neighbor interactions both have significant effects on the position of the phase boundaries. Improved stability domains for the $\eta$-pairing state and for the fully saturated ferromagnetic state at half filling have been constructed. The results show that these states are the ground states for model Hamiltonians with realistic values of the interaction parameters.Comment: 21 pages (10 figures are included) Revtex, revised version. To be published in Phys. Rev. B. E-mail: [email protected]

Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells

IL-2 is the primary growth factor for promoting survival and proliferation of activated T cells that occurs following engagement of the Janus Kinase (JAK)1-3/and Signal Transducer and Activator of Transcription (STAT) 5 signaling pathway. STAT5 has two isoforms: STAT5A and STAT5B ( commonly referred to as STAT5) which, in T cells, play redundant roles transcribing cell cycle and survival genes. As such, inhibition of STAT5 by a variety of mechanisms can rapidly induce apoptosis in certain lymphoid tumor cells, suggesting that it and its target genes represent therapeutic targets to control certain lymphoid diseases. To search for these molecules we aligned IL-2 regulated genes detected by Affymetrix gene expression microarrays with the STAT5 cistrome identified by chip-on-ChIP analysis in an IL-2-dependent human leukemia cell line, Kit225. Select overlapping genes were then validated using qRT(2)PCR medium-throughput arrays in human PHA-activated PBMCs. Of 19 putative genes, one key regulator of T cell receptor signaling, PDE4B, was identified as a novel target, which was readily up-regulated at the protein level (3 h) in IL-2 stimulated, activated human PBMCs. Surprisingly, only purified CD8+ primary T-cells expressed PDE4B, but not CD4+ cells. Moreover, PDE4B was found to be highly expressed in CD4+ lymphoid cancer cells, which suggests that it may represent a physiological role unique to the CD8+ and lymphoid cancer cells and thus might represent a target for pharmaceutical intervention for certain lymphoid diseases

Tissue levels of active matrix metalloproteinase-2 and -9 in colorectal cancer

The bioactivity of matrix metalloproteinases was studied in tissues from colorectal cancer patients by means of both quantitative gelatin zymography and a fluorometric activity assay. Next to paired samples of tumour tissue and distant normal mucosa (n=73), transitional tissue was analysed from a limited (n=33) number of patients. Broad-spectrum matrix metalloproteinase activity and both the active and latent forms of the gelatinases matrix metalloproteinase-2 and -9 were higher in tumour than in normal mucosa. The ratio's between active and latent forms of matrix metalloproteinase-2 and -9 were highest in tumour tissue and normal mucosa, respectively. Matrix metalloproteinase-2 levels, both active and latent forms, correlated inversely with stage of disease, the tumours without synchronous distant metastases containing significantly (P=0.005) more active matrix metalloproteinase-2 than the others. At much lower levels of activity, the same trend was observed in distant normal mucosa. The level of latent form of matrix metalloproteinase-9 in tumour depended on tumour location. Neither the active form of matrix metalloproteinase-9 nor broad-spectrum matrix metalloproteinase activity in tumour tissue did correlate with any of the clinicopathological parameters investigated. The results demonstrate explicit differences between the activity of matrix metalloproteinase-2 and -9, indicating different roles for both gelatinases in tumour progression. Such data are necessary in order to develop rational anti-cancer therapies based on inhibition of specific matrix metalloproteinases

Structure of 136Sn and the Z = 50 magicity

The first 2+ excited state in the neutron-rich tin isotope 136Sn has been identified at 682(13) keV by measuring γ -rays in coincidence with the one proton removal channel from 137Sb. This value is higher than those known for heavier even-even N = 86 isotones, indicating the Z = 50 shell closure. It compares well to the first 2+ excited state of the lighter tin isotope 134Sn, which may suggest that the seniority scheme also holds for 136Sn. Our result confirms the trend of lower 2+ excitation energies of even-even tin isotopes beyond N = 82 compared to the known values in between the two doubly magic nuclei 100Sn and 132Sn. © The Author(s) 2014.published_or_final_versio

A Study on Field Emission Characteristics of Planar Graphene Layers Obtained from a Highly Oriented Pyrolyzed Graphite Block

This paper describes an experimental study on field emission characteristics of individual graphene layers for vacuum nanoelectronics. Graphene layers were prepared by mechanical exfoliation from a highly oriented pyrolyzed graphite block and placed on an insulating substrate, with the resulting field emission behavior investigated using a nanomanipulator operating inside a scanning electron microscope. A pair of tungsten tips controlled by the nanomanipulator enabled electric connection with the graphene layers without postfabrication. The maximum emitted current from the graphene layers was 170 nA and the turn-on voltage was 12.1 V